In-depth explanations of the genetics, databases and research behind DNA health reports.
4 articles
Deep dives · 11 min read
Where APOE ε4 sits in a 23andMe or AncestryDNA raw file, the rs429358 and rs7412 genotype table, why Ancestry files can hide ε4, and what the odds ratios mean.
Deep dives · 11 min read
Find rs2187668 (HLA-DQ2.5) and rs7454108 (DQ8) in a 23andMe or AncestryDNA raw file, read them off a genotype table, and learn why a negative result is the useful one.
Deep dives · 11 min read
Where rs1801133 and rs1801131 sit in a 23andMe raw file, which letters mean C677T and A1298C, what the evidence shows, and why a GWAS-based report does not score MTHFR.
Deep dives · 11 min read
What the NHGRI-EBI GWAS Catalog is, which studies it accepts, how Full Human filters 1.2 million associations down to 23,220 rows, and what a row in your PDF maps to.
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